Mike don't worry about switching between regular, E10 or E85. The flex fuel vehicles have a sensor to determine the ethanol mixture and automatically compensate. You can use either E85 or regular to tow with.
I would make it a point to fill up at gas stations that have a large turnover of fuel to prevent excess moisture problems in the fuel. Also be religious in changing your fuel filter at or before scheduled times.
I also wouldn't worry about the 6.2 not having enough power to pull. It is rated at 385 HP and 405 LBS torque. The last year of the 460 made 245 HP and 395LBS torque. My 2000 7.3 power stroke makes 250 HP and 500 LBS torque.
Your truck has a 6 speed automatic,and considering how well the ones here at work hold up, it won't let you down. I can show you 3 in F550's with almost a million miles combined, and 100% of that time is near full GVWR, 18,000 pounds and NOT babied at all, complete abuse is more like it. Just be sure to click tow haul, and remember that the 6.2 likes to rev, and you'll be happy and pleased.
Later
Hank